Tildipirosin
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Tildipirosin
Tildipirosin bụ ụdị ọhụrụ nke ọgwụ nje macrolide mgbanaka nwere akụkụ iri na isii, nke bụ ihe sitere na tylosin.
Pharmacological omume
Mmetụta antibacterial nke Tildipirosin yiri nke tylosin, ọ na-enwekwa mmetụta mgbochi siri ike na nje bacteria gram-positive na ụfọdụ nje bacteria Gram-negative.Usoro antibacterial nke Tildipirosin bụ otu nke macrolides.Ọ nwere ike ijikọta ya na mpaghara 50S nke ribosome nke nje bacteria na-emetụ n'ahụ iji gbochie njikọ nke riboprotein peptide chains, si otú ahụ na-emetụta njikọ nke protein protein.Mmekọrịta nke ihe abụọ piperidine pụrụ iche na Tildipirosin na-eme ka usoro ọrụ nke ọgwụ a dị na tylosin na tilmicosin, ebe a na-eduzi 20-piperidine n'ime lumen iji gbochie uto nke peptides na-amụba.
N'ihi na tediroxine nwere otu amino isi atọ, ọ nwere ike ịmepụta ụdị ebubo dị iche iche n'okpuru ọnọdụ pH dị iche iche.Ọnụ ego a na-akwụ bụ isi ihe na-eme ka ọ ghara ịdị irè nke lipids nje ma banye n'ime mpụta nke nje bacteria Gram-negative, ya mere pH na-emetụta ọrụ bacteriostatic nke Tildipirosin in vitro.N'okpuru ọnọdụ acidic, amino group na-emepụta protonated, na-ebute mbelata ọrụ antibacterial nke tediroxine, ebe n'okpuru ọnọdụ alkaline, ọ nwere ọrụ antibacterial siri ike.
Macrolides na-egbochi nzuzo nke cytokines proinflammatory, ọrụ phospholipase, na ntọhapụ leukotriene, ma nwee mmetụta mgbochi mkpali na macrophages na neutrophils.Tediroxine na-ebelata ndị mgbasa ozi mkpali emepụtara n'oge ụfọdụ mmeghachi omume mkpali ma ọ bụ nrụgide.
Antibacterial ụdịdị dị iche iche
Tildipirosin dị irè megide nje bacteria na-akpata ọrịa iku ume na ezì na anụ ụlọ (dị ka Pasteurella multocida, Actinobacillus pleuropneumoniae, Bordetella bronchiseptica, Haemophilus parasuis, Mannheim spp. wdg) ọrụ antibacterial nke tilmicosin bụ 2-32 ugboro dị elu karịa nke tilmicosin. , na ọrụ antibacterial megide Escherichia coli intestinal dị mma karịa tylosin na tilmicosin.Ọ na-enwekwa mmetụta maka ụfọdụ mycoplasma strains, spirochetes, brucella, wdg. Nnyocha egosiwo na tediroxine nwere mmetụta bacteriostatic siri ike na Haemophilus parasuis na Bordetella bronchiseptica karịa florfenicol, mana mmetụta bacteriostatic na-esighị ike na Actinobacillus pleuropneumoniae na Pasteurella mulze.Tildipirosin na-ebute nje bacteria ụfọdụ (dị ka Haemophilus parasuis na Actinobacillus pleuropneumoniae), ebe ọ na-ebutekarị nje bacteria (dị ka Pasteurella multocida).Maka nje bacteria nke eriri afọ, na mbelata nke pH uru (site na 7.3 ruo 6.7), MIC nke Tildipirosin mụbara, dịka ọmụmaatụ, MIC nke Tildipirosin megide Salmonella Enteritidis na Escherichia coli nwere ike ịbawanye site na 2 ~ 8ug / m ruo 64 ~ 256ug / mL. .Ya mere, ekwesịrị ịtụle mmetụta nke mgbanwe pH na vivo mgbe ị na-eme nnwale nje antibacterial in vivo nke Tildipirosin.Tụkwasị na nke ahụ, MIC nke Tildipirosin megide ụdị ụdị Pasteurella multocida bụ 0.5ug / mL na serum, nke bụ 0.25 ugboro dị ala karịa nke ahụ na vitro, nke nwere ike jikọta ya na mmetụta serum.
Enterococcus-Streptococcus na ehi mmiri ara ehi na-eguzogide ọgwụ tediroxine nke ukwuu.Tildipirosin enweghị mmetụta na Pasteurella multocida na Mannheimia haemolyticus na-ebu mkpụrụ ndụ ihe nketa.N'otu aka ahụ, ụdị mkpụrụ ndụ ihe nketa nke M. bovis na-eguzogide ọgwụ nje macrolide gụnyere Tildipirosin.A chọpụtakwara na ụfọdụ ụdị haemophilus parasuis na-eguzogide ọgwụ tediroxine.Mycoplasma bovis nwere ike nweta iguzogide Tildipirosin ngwa ngwa, mana n'ihi uto ngwa ngwa nke Mycoplasma, nnwale in vitro nwere ike igbu oge ọgwụgwọ.Nnyocha egosiwo na ngalaba II (nucleotide 748) na ngalaba V (Mgbanwe na nucleotides 2059 na 2060) na-ejikọta ya na iguzogide macrolides.Ya mere, enwere ike nweta ike nke M. bovis na ọgwụ macrolide ngwa ngwa site na nyocha nke mkpụrụ ndụ ihe nketa a.
Ọdịnaya
≥ 98%
Nkọwapụta
Ụkpụrụ ụlọ ọrụ
Hebei Veyong Pharmaceutical Co., Ltd, e guzobere na 2002, emi odude ke Shijiazhuang City, Hebei Province, China, na-esote Isi Obodo Beijing.Ọ bụ nnukwu ụlọ ọrụ ọgwụ anụmanụ enwetara ikike nke GMP, yana R&D, mmepụta na ire nke API ọgwụgwọ anụmanụ, nkwadebe, nri agbakwunyere na mgbakwunye nri.Dị ka Provincial Technical Center, Veyong eguzobela usoro R&D ọhụrụ maka ọgwụ anụmanụ ọhụrụ, ma bụrụ ụlọ ọrụ mmepụta ihe ọhụrụ na teknụzụ nke mba ama ama, enwere ndị ọkachamara teknụzụ 65.Veyong nwere abụọ mmepụta bases: Shijiazhuang na Ordos, nke Shijiazhuang isi na-ekpuchi ebe 78,706 m2, na 13 API ngwaahịa gụnyere Ivermectin, Eprinomectin, Tiamulin Fumarate, Oxytetracycline hydrochloride ects, na 11 nkwadebe mmepụta akara gụnyere injection, oral ngwọta, ntụ ntụ ngwọta. , premix, bolus, pesticides na disinfectant, wdg.Veyong na-enye API, ihe karịrị 100 nkwado akara aha, yana ọrụ OEM & ODM.
Veyong na-etinye aka na njikwa nke sistemụ EHS (Environment, Health & Safety), ma nweta asambodo ISO14001 na OHSAS18001.Edepụtara Veyong n'ime ụlọ ọrụ mmepụta ihe na-emepụta atụmatụ dị na Hebei Province ma nwee ike hụ na ngwaahịa na-aga n'ihu.
Veyong guzobere usoro njikwa mma zuru oke, nweta asambodo ISO9001, asambodo China GMP, asambodo Australia APVMA GMP, asambodo Ethiopia GMP, asambodo Ivermectin CEP, wee gafere nyocha US FDA.Veyong nwere ọkachamara otu ndebanye aha, ahịa na ọrụ teknụzụ, ụlọ ọrụ anyị enwetala ntụkwasị obi na nkwado site n'aka ọtụtụ ndị ahịa site n'ịdị mma ngwaahịa dị mma, ọrụ tupu ire ere na mgbe ire ere, ọrụ siri ike na sayensị.Veyong emewo ogologo okwu imekọ ihe ọnụ na ọtụtụ mba ụwa maara na-emepụta ọgwụ ụlọ ọrụ na ngwaahịa exported na Europe, South America, Middle East, Africa, Asia, wdg karịa 60 mba na mpaghara.
