20% Albendazole Granule
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Nkà mmụta ọgwụ
Albendazole bụ ihe nrụpụta benzimidazole, nke nwere ike ime ngwa ngwa n'ime ahụ ya ka ọ bụrụ sulfoxide, mmanya sulfone na mmanya 2-aminosulfone.Ọ na-ahọrọ na nke na-adịghị agbanwe agbanwe na-egbochi polymerization nke sistemu microtubule cytoplasmic nke mkpụrụ ndụ mgbidi eriri afọ nke parasaiti maka nematodes intestinal, nke nwere ike igbochi nnabata na nnabata nke ihe oriri na glucose dị iche iche, na-eduga na ike ọgwụgwụ nke glycogen endogenous n'ime ụmụ ahụhụ, ma gbochie. fumarate reductase Usoro na-egbochi mmepụta nke adenosine triphosphate ma na-egbochi ndụ na mmepụta nke ikpuru.Dị ka mebendazole, ngwaahịa a nwekwara ike ime ka mmebi nke cytoplasmic microtubules nke eriri afọ nke ikpuru, na-ejikọta ya na tubulin ya, na-akpata nkwụsị nke njem intracellular, na-eme ka mkpokọta Golgi endocrin granules, mgbasa nke cytoplasmic nwayọọ nwayọọ, na mmebi zuru oke nke absorption. mkpụrụ ndụ.Na-akpata ọnwụ nke ikpuru.20% albendazole granulenwere ike gbuo akwa hookworm kpamkpam na akwa whipworm ma gbuo akụkụ ụfọdụ.Na mgbakwunye na igbu na ịchụpụ nematodes dị iche iche bụ ndị na-egbu egbu n'ime anụmanụ, ọ nwekwara mmetụta igbu ọchụ doro anya na ịkpaghasị mmetụta na tapeworms na cysticercus.
Toxicology
Nnwale toxicological na-egosi na ngwaahịa a nwere obere toxicity yana ọ dị mma.LD50 ọnụ maka ụmụ oke karịrị 800mg/kg, yana oke nnabata maka nkịta karịrị 400mg/kg.Ọgwụ a enweghị mmetụta na ọrụ ịmụ nwa nke ụmụ oke nwoke, ọ nweghịkwa mmetụta teratogenic na ụmụ oke nwanyị.Mmụba nwa ebu n'afọ nwere ike ime mgbe etinyere oke dose [30 mg/(㎏·day)] na oke ụmụ nwanyị na oke bekee nwanyị.Na skeletal deformities.
Ojiji na usoro onunu ogwu
Dabere na albendazole.nchịkwa ọnụ: otu ugboro, 25 ~ 50mg / kg arọ ahụ.Ma ọ bụ soro ndụmọdụ dọkịta.
Mmeghachi omume ọjọọ
(1) mgbe e nyere nkịta 50 mg / kg ugboro abụọ n'ụbọchị, ha na-eji nwayọọ nwayọọ na-azụlite anorexia
(2) Ojiji albendazole na mmalite ime ime nwere ike iso ya na teratogenicity na embrayotoxicity.
Rịba ama
Ụmụ anụmanụ kwesịrị ịkpachara anya n'ime ụbọchị 45 mbụ mgbe imechara ime
Hebei Veyong Pharmaceutical Co., Ltd, e guzobere na 2002, emi odude ke Shijiazhuang City, Hebei Province, China, na-esote Isi Obodo Beijing.Ọ bụ nnukwu ụlọ ọrụ ọgwụ anụmanụ enwetara ikike nke GMP, yana R&D, mmepụta na ire nke API ọgwụgwọ anụmanụ, nkwadebe, nri agbakwunyere na mgbakwunye nri.Dị ka Provincial Technical Center, Veyong eguzobela usoro R&D ọhụrụ maka ọgwụ anụmanụ ọhụrụ, ma bụrụ ụlọ ọrụ mmepụta ihe ọhụrụ na teknụzụ nke mba ama ama, enwere ndị ọkachamara teknụzụ 65.Veyong nwere abụọ mmepụta bases: Shijiazhuang na Ordos, nke Shijiazhuang isi na-ekpuchi ebe 78,706 m2, na 13 API ngwaahịa gụnyere Ivermectin, Eprinomectin, Tiamulin Fumarate, Oxytetracycline hydrochloride ects, na 11 nkwadebe mmepụta akara gụnyere injection, oral ngwọta, ntụ ntụ ngwọta. , premix, bolus, pesticides na disinfectant, wdg.Veyong na-enye API, ihe karịrị 100 nkwado akara aha, yana ọrụ OEM & ODM.
Veyong na-etinye aka na njikwa nke sistemụ EHS (Environment, Health & Safety), ma nweta asambodo ISO14001 na OHSAS18001.Edepụtara Veyong n'ime ụlọ ọrụ mmepụta ihe na-emepụta atụmatụ dị na Hebei Province ma nwee ike hụ na ngwaahịa na-aga n'ihu.
Veyong guzobere usoro njikwa mma zuru oke, nweta asambodo ISO9001, asambodo China GMP, asambodo Australia APVMA GMP, asambodo Ethiopia GMP, asambodo Ivermectin CEP, wee gafere nyocha US FDA.Veyong nwere ọkachamara otu ndebanye aha, ahịa na ọrụ teknụzụ, ụlọ ọrụ anyị enwetala ntụkwasị obi na nkwado site n'aka ọtụtụ ndị ahịa site n'ịdị mma ngwaahịa dị mma, ọrụ tupu ire ere na mgbe ire ere, ọrụ siri ike na sayensị.Veyong emewo ogologo okwu imekọ ihe ọnụ na ọtụtụ mba ụwa maara na-emepụta ọgwụ ụlọ ọrụ na ngwaahịa exported na Europe, South America, Middle East, Africa, Asia, wdg karịa 60 mba na mpaghara.
